Responder components will not communicate properly if one or more machines are using the incorrect network interface to communicate. Network interface binding determines which network interface (e.g., network card) Responder uses on the local machine (or in the cluster) to communicate with external Responder components. If you have multiple network interfaces, then network interface binding must be specified for MSMQ .NET Remoting Channel, Responder PubSub and Responder Events on each machine. The binding points to a particular network interface address. In most instances, all three of these will use the same network interface address.
The Control Network Interface Binding page in the Configuration Guide discusses how to configure this setting.